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Abstract #8593 Published in IGR 5-1
Five-year results of trabeculectomy with mitomycin C
Beckers HJM; Kinders KC; Webers CABGraefe's Archive for Clinical and Experimental Ophthalmology 2003; 241: 106-110
BACKGROUND: The long-term efficacy and safety of primary trabeculectomy with mitomycin C were retrospectively studied. METHODS: Sixty eyes of 60 patients with severe glaucoma (25 female, 35 male) with a mean age of 72.5 years, who underwent primary trabeculectomy with mitomycin C between 1993 and 1995, were included. Glaucoma subtypes consisted of 42 patients with primary open-angle glaucoma, ten with normal-pressure glaucoma, two with chronic narrow-angle glaucoma, five with pigment dispersion syndrome, and one with pseudoexfoliation syndrome. During surgery, mitomycin C 0.2 mg/ml was applied under the scleral flap for three minutes. RESULTS: Mean intraocular pressure (IOP) decreased from 22.3 ± 9.3 preoperatively to 12.6 ± 3.5 mmHg postoperatively. With success defined as an IOP level of 15 mmHg or less, a success rate of 83.3% was obtained in the first year, dropping to 60% in the sixth year following trabeculectomy. Visual fields remained stable in 73.3% of cases during the follow-up period. LogMAR visual acuity increased from 0.2 to 0.4. Four eyes underwent cataract surgery prior to trabeculectomy. Thirteen eyes underwent cataract surgery during the follow-up period. Long-term complications were relatively mild and consisted of two cases of blebitis. Bleb reconstruction was performed in five eyes with overfiltration or bleb-related complaints. CONCLUSION: The present findings indicate that the additional use of mitomycin C may be justified in trabeculectomies in patients with severe glaucoma.
Dr. H.J.M. Beckers, University Eye Clinic, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands. hbec@soog.azm.nl
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
