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Abstract #86080 Published in IGR 21-2
Continuous anti-glaucoma drug therapy as a risk factor of dry eye
Erichev VP; Petrov SY; Petrov SY; Petrov SY; Petrov SY; Volzhanin AV; Volzhanin AV; Volzhanin AV; Volzhanin AV; Ghazaryan SAVestnik Oftalmologii 2019; 135: 117-123
A preservative is a mandatory component of the eye drops designed to prevent microbial contamination in an opened bottle. Most of the preservative agents are either detergents, or oxidants; the most widely used and well-studied preservative - benzalkonium chloride - is a detergent. Due to regular usage of glaucoma eye drops, cytotoxic impact of the preservatives on anterior eye surface is considered the principal cause of its pathology, which leads to a decrease in quality of life. The high cost of preservative-free pharmacological forms and the complicated process of developing new preservatives make the usage of eye drops with minimal required concentration of preservative agent and a moistening component a good compromise. The most commonly utilized moistening component is polyvinyl alcohol - synthetic polymeric hydrogel, which is also used in artificial tears and bioengineering.
Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.
Full articleClassification:
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
