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1 General aspects (0)   1.1 Epidemiology (6)   1.2 Population genetics (0)   1.3 Pathogenesis (0)   1.4 Quality of life (13)   1.5 Glaucomas as cause of blindness (5)   1.6 Prevention and screening (3) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (5)   2.2 Cornea (19)   2.3 Sclera (11)   2.4 Anterior chamber angle (3)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (10)     2.5.2 Schlemms canal (1)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (1)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (6)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (6)   2.9 Ciliary body (0)   2.10 Lens (0)   2.11 Vitreous body (1)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (15)   2.13 Retina and retinal nerve fibre layer (17)   2.14 Optic disc (28)   2.15 Optic nerve (0)   2.16 Chiasma and retrochiasmal central nervous system (5)   2.17 Stem cells (4)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (0)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (2)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (0)     3.4.2 Gene studies (18)   3.5 Molecular biology incl. 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(11) 8 Refractive errors in relation to glaucoma (0)   8.1 Myopia (4)   8.2 Hypermetropia (0)   8.3 Contact lenses (5)   8.4 Refractive surgical procedures (0)   8.5 Other (0) 9 Clinical forms of glaucomas (0)   9.1 Developmental glaucomas (0)     9.1.1 Congenital glaucoma, Buphthalmos (9)     9.1.2 Juvenile glaucoma (17)     9.1.3 Syndromes of Axenfeld, Rieger, Peters, aniridia (3)     9.1.4 Other (1)   9.2 Primary open angle glaucomas (0)     9.2.1 Ocular hypertension (6)     9.2.2 Other risk factors for glaucoma (6)     9.2.3 Open angle glaucoma with elevated IOP (2)     9.2.4 Normal pressure glaucoma (14)   9.3 Primary angle closure glaucomas (0)     9.3.1 Acute primary angle closure glaucoma (pupillary block) (7)     9.3.2 Chronic primary angle closure glaucoma (pupillary block) (4)     9.3.3 Plateau iris syndrome (0)     9.3.4 Primary angle closure suspect (1)     9.3.5 Primary angle closure (2)     9.3.10 Other (1)   9.4 Glaucomas associated with other ocular and systemic disorders (0)     9.4.1 Steroid-induced glaucoma (2)     9.4.2 Glaucomas associated with disorders of the cornea, conjunctiva, sclera (1)       9.4.2.1 Iridocorneal endothelial syndrome (ICE, incl. irisatrophy) (1)       9.4.2.2 Posterior polymorphous dystrophy (0)       9.4.2.3 Fuchs' endothelial dystrophy (0)       9.4.2.5 Other (1)     9.4.3 Glaucomas associated with disorders of the iris and ciliary body (0)       9.4.3.1 Pigmentary glaucoma (2)       9.4.3.5 Other (0)     9.4.4 Glaucomas associated with disorders of the lens (0)       9.4.4.1 Exfoliation syndrome (22)       9.4.4.2 Glaucomas associated with cataracts (1)       9.4.4.3 Glaucomas associated with lens dislocation (1)       9.4.4.5 Other (1)     9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous (0)       9.4.5.1 Neovascular glaucoma (9)       9.4.5.5 Other (7)     9.4.6 Glaucomas associated with inflammation, uveitis (7)     9.4.7 Glaucomas associated with ocular trauma (2)     9.4.8 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surgery (1)     12.8.1 Without tube implant (15)     12.8.2 With tube implant or other drainage devices (46)     12.8.3 Non-perforating (4)     12.8.4 Using laser (1)     12.8.5 Other (1)     12.8.10 Woundhealing antifibrosis (12)     12.8.11 Complications, endophthalmitis (11)   12.9 Trabeculotomy, goniotomy (8)   12.10 Cyclodestruction (9)   12.11 Cyclodialysis (0)   12.12 Cataract extraction (0)     12.12.1 Intracapsular (0)     12.12.2 Extracapsular (0)     12.12.3 Phacoemulsification (8)   12.14 Combined cataract extraction and glaucoma surgery (0)     12.14.1 Intracapsular (0)     12.14.2 Extracapsular (0)     12.14.3 Phacoemulsification (4)   12.15 Capsulotomy (0)   12.16 Vitrectomy (4)   12.17 Anesthesia (1)   12.20 Other (2) 13 Therapeutic prognosis and outcome (0)   13.1 Prognostic factors (0)   13.2 Outcome (0)     13.2.1 IOP (0)     13.2.2 Visual field (0)       13.2.2.1 Progression (0)       13.2.2.2 Improvement (1)     13.2.3 Other (0) 14 Costing studies; pharmacoeconomics (6) 15 Miscellaneous (28)

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Abstract #86121 Published in IGR 21-2

Glaucoma in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA): cohort profile, prevalence, awareness and associations

McCann P; Hogg R; Wright DM; Pose-Bazarra S; Chakravarthy U; Peto T; Cruise S; McGuinness B; Young IS; Kee F; Azuara-Blanco A
British Journal of Ophthalmology 2020; 104: 1492-1499

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BACKGROUND/AIMS: This study aimed to describe the cohort profile of the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) and to report the prevalence of, awareness of and associations with glaucoma. METHODS: Using geographic stratification, a representative sample of non-institutionalised Northern Irish adults aged over 50 years was invited to participate. NICOLA participants underwent a Computer-Assisted Personal Interview (CAPI), a Self-Completion Questionnaire (SCQ) and a health assessment. The CAPI and SCQ collected comprehensive sociodemographic and health-related data. At the health assessment, participants underwent optic disc stereophotography, intraocular pressure (IOP) measurement using ocular response analyser (ORA), autorefraction, spectral domain optical coherence tomography and self-reported history of glaucoma. We invited NICOLA participants suspected of having glaucoma due to optic disc appearance or raised IOP for clinical examination by a glaucoma expert and perimetry. Epidemiological definitions by the International Society Geographical and Epidemiological Ophthalmology were used to define glaucoma. RESULTS: Of 3221 NICOLA participants (mean age 64.4, SD 8.5, female sex 51.7%) who attended the health assessment component of the NICOLA study (and had a vertical cup to disc ratio measurement in at least one eye), 91 participants had glaucoma. Overall, the crude prevalence of glaucoma was 2.83% (95% CI 2.31% to 3.46%) and 67% of affected individuals did not give a self-reported history of glaucoma. CONCLUSIONS: The prevalence of glaucoma in Northern Ireland is comparable with other population-based studies of European populations. Approximately two-thirds of people with glaucoma were undiagnosed.

Centre for Public Health, Queen's University Belfast, Belfast, UK.

Full article

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Classification:

1.1 Epidemiology (Part of: 1 General aspects)

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