advertisement
Abstract #86367 Published in IGR 21-2
Diagnostic power of scleral spur length in primary open-angle glaucoma
Li M; Luo Z; Yan X; Zhang HGraefe's Archive for Clinical and Experimental Ophthalmology 2020; 258: 1253-1260
PURPOSE: To investigate the diagnostic capability of scleral spur length in discriminating eyes with primary open-angle glaucoma (POAG) from healthy eyes. METHODS: Seventy-eight eyes of 78 patients with POAG and 93 eyes of 93 age-, sex- and axial length-matched healthy subjects were included. The scleral spur length was measured using swept-source optical coherence tomography. Receiver operating characteristic (ROC) curves were derived based on the measurements. RESULTS: The scleral spur length was significantly shorter in POAG eyes compared with healthy eyes ( Method I, 164.91 ± 23.36 vs. 197.60 ± 25.32 μm; Method II, 145.15 ± 16.59 vs. 166.95 ± 19.31 μm; Method III, 162.33 ± 22.83 vs. 185.12 ± 23.58 μm, respectively; all p < 0.001). The areas under ROC curves were 0.841 ( Method I), 0.810 ( Method II), and 0.753 ( Method III) for the scleral spur length. Moreover, Schlemm's canal area was significantly associated with the scleral spur length ( Method I) in both POAG (β = 0.027; p < 0.001) and healthy (β = 0.016; p = 0.009) groups. CONCLUSIONS: The scleral spur length had a good discriminating capability between POAG and healthy eyes, and it could be a novel biomarker for POAG evaluation clinically.
Full article
Classification:
2.3 Sclera (Part of: 2 Anatomical structures in glaucoma)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
