advertisement
Abstract #8660 Published in IGR 5-1
Hypotensive effect of timolol and latanoprost instillation in normal-tension glaucoma
Hashimoto T; Hara T; Takahashi Y; Kubota S; Kubota M; Tsuru TJapanese Journal of Clinical Ophthalmology 2003; 57: 288-291
The authors evaluated the hypotensive effect of topical timolol gel and latanoprost in 33 patients with normal-tension glaucoma. With the single use of timolol, the intraocular pressure (IOP) decreased from 15.0 ± 1.9 to 13.3 ± 2.8 mmHg after four weeks (p < 0.01). With the single use of latanoprost, IOP decreased from 15.9 ± 1.9 to 13.2 ± 2.2 mmHg four weeks later (p < 0.01). When latanoprost was added to timolol, IOP decreased from 13.3 ± 2.8 to 11.1 ± 2.5 mmHg (p < 0.01). When timolol was added to latanoprost, IOP decreased from 13.2 ± 2.2 to 12.0 ± 3.3 mmHg (p < 0.05). The success rate of decreasing IOP by 20 or 30% from the baseline was 20.0 and 15.0% with timolol and increased to 65.0 and 40.0% with dual instillation. The success rate was 38.5 and 7.7% with latanoprost and increased to 46.2 and 30.8%. These findings show that a significant hypotensive effect can be obtained by the single use of timolol or latanoprost in normal-tension glaucoma. Dual instillation induces a greater hypotensive effect.LA: Japanese
Dr. T. Hashimoto, Department of Ophthalmology, Jichi Medical School, 3311-1 Yakushiji Minamikawachi-machi, Kawachi-gun Tochigi-ken 329-0498, Japan
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
