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1 General aspects (0)   1.1 Epidemiology (6)   1.2 Population genetics (0)   1.3 Pathogenesis (0)   1.4 Quality of life (13)   1.5 Glaucomas as cause of blindness (5)   1.6 Prevention and screening (3) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (5)   2.2 Cornea (19)   2.3 Sclera (11)   2.4 Anterior chamber angle (3)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (10)     2.5.2 Schlemms canal (1)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (1)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (6)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (6)   2.9 Ciliary body (0)   2.10 Lens (0)   2.11 Vitreous body (1)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (15)   2.13 Retina and retinal nerve fibre layer (17)   2.14 Optic disc (28)   2.15 Optic nerve (0)   2.16 Chiasma and retrochiasmal central nervous system (5)   2.17 Stem cells (4)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (0)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (2)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (0)     3.4.2 Gene studies (18)   3.5 Molecular biology incl. 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pharmacoeconomics (6) 15 Miscellaneous (28)

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Abstract #86815 Published in IGR 21-2

Aqueous Inflammation and Ischemia-Related Biomarkers in Neovascular Glaucoma with Stable Iris Neovascularization

Sun C; Zhang H; Tang Y; Chen Y; Li Y; Nie C; Gu J; Luo L; Wang Z
Current Eye Research 2020; 0: 1-10

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: To characterize the aqueous levels of inflammation and ischemia-related biomarkers in a spectrum of retinal ischemic conditions, including neovascular glaucoma (NVG) with stable iris neovascularization after pan retinal photocoagulation (PRP) and anti-VEGF treatment.: Aqueous samples were collected from 139 eyes including NVG (n = 12), stable NVG (n = 26), CRVO (n = 11), NPDR (n = 18), PACG (n = 18), PDR (n = 25), BRVO (n = 7) and cataract (n = 22). The levels of VEGF-A, IL-8 and EPO were measured with ELISA.: Aqueous VEGF-A significantly decreased after anti-VEGF and PRP, from 983.79 ± 821.16 pg/ml in the NVG group (n = 11) to 256.50 ± 51.14 pg/ml in the stable NVG group (n = 24) ( = .015). Aqueous VEGF-A in stable NVG group (256.50 ± 51.14 pg/ml, n = 24) was significantly higher (ANOVA, < .001) than in CRVO (212.10 ± 19.84 pg/ml, n = 7, = .017), NPDR (221.18 ± 38.21 pg/ml, n = 14, = .015), BRVO (213.14 ± 48.50 pg/ml, n = 6, = .028) and cataract group (185.30 ± 34.35 pg/ml, n = 22, < .001). Aqueous IL-8 in stable NVG group (74.82 ± 10.78 pg/ml, n = 24) was significantly higher (ANOVA, < .001) than in CRVO (65.19 ± 15.34 pg/ml, n = 11, = .032) and cataract group (54.11 ± 12.28 pg/ml, n = 22, < .001). Aqueous EPO in stable NVG group (17.48 ± 3.02 pg/ml, n = 24) was significantly higher (ANOVA, < .001) than in BRVO (14.98 ± 2.57 pg/ml, n = 7, = .034) and cataract group (13.50 ± 2.65 pg/ml, n = 22, < .001). Aqueous concentrations of VEGF-A and IL-8 correlated positively with IOP (r = 0.413, < .001, r = 0.349, < .001, respectively, r = correlation coefficient). VEGF-A correlated positively with IL-8 and EPO ( < .001, = .002, respectively). IL-8 correlated positively with EPO ( < .001).: The aqueous levels of VEGF-A, IL-8 and EPO in NVG patients with stable iris neovascularization, who had received PRP and anti-VEGF, were still significantly higher than in control groups with some retinal ischemic conditions.

Department of Ophthalmology, China-Japan Friendship Hospital, Beijing, China.

Full article

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Classification:

9.4.5.1 Neovascular glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous)
9.4.6 Glaucomas associated with inflammation, uveitis (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
3.7 Biochemistry (Part of: 3 Laboratory methods)
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)

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