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Abstract #8733 Published in IGR 5-1
Transient, profound cataract associated with intracameral 5-fluorouracil
Libre PEAmerican Journal of Ophthalmology 2003; 135: 101-102
PURPOSE: To report a transient cataract after bleb needling and subconjunctival injection of 5-fluorouracil. DESIGN: Observational case report. METHODS: A 51-year-old man had an encapsulated bleb after filtering surgery. The bleb was needled, and 5 mg of 5-fluorouracil was injected adjacent to the bleb. RESULTS: Within five minutes, vision fell to finger counting at one foot, owing to anterior lens capsule opacification. The next day, acuity and lens clarity had returned to their preneedling status. Best-corrected acuity seven months later was 20/15. CONCLUSIONS: Entry of 5-fluorouracil into the anterior chamber after bleb needling can cause transient lens opacification. Recently, intracameral 5-fluorouracil was reported as a new treatment for epithelial ingrowth. Given the transient cataract observed in this case, the use of 5-fluorouracil for epithelial ingrowth should be considered with caution for phakic patients.
Dr. P.E. Libre, Department of Ophthalmology, Columbia University, New York, NY, USA
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
