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Abstract #8856 Published in IGR 5-1
Effect of negative pressure suction on rabbit optic nerve and retina
Ye A; Pang G; Han YChinese Journal of Ophthalmology 2003; 39: 136-
OBJECTIVE: To study the effect of acute intraocular pressure (IOP) elevation on the optic nerve and retina in laser in situ keratomileusis (LASIK). METHODS: Acute IOP was increased in rabbit eyes to 65 mmHg for different periods of time (30 seconds, one and three minutes) by using scleral suction. The tissue of the retina and optic nerve of the immediately extirpated group (instant group) and of the group extirpated two weeks later (recovery group), both after negative pressure suction, and of normal rabbit eyes, was examined by electron and light microscopy. RESULTS: After negative pressure suction for 30 seconds, one minute, and three minutes, respectively, the optic nerve and retinal cells changed slightly; some parts of the optic nerve and retinal cells changes; optic nerve fibers and retinal cells changed sharply. CONCLUSIONS: Ultrastructural changes of the retina and optic nerve may be induced by acute IOP elevation in LASIK. The longer the time, the more apparent the changes.LA: Chinese
Dr. A. Ye, Eye Research Center, Chinese Academy of Medical Sciences & Chinese Union Medical College, Department of Ophthalmology, Peking Union Medical College Hospital, Beijing 100730, China. awai@263.net
Classification:
8.4 Refractive surgical procedures (Part of: 8 Refractive errors in relation to glaucoma)