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Abstract #8948 Published in IGR 5-2
Comparison between latanoprost and brimonidine efficacy and safety in Indian eyes
Thomas R; Parikh R; Muliyil J; George R; Paul P; Abraham LMIndian Journal of Ophthalmology 2003; 51: 123-128
PURPOSE: To compare the short-term efficacy and safety of topical latanoprost and brimonidine in Indian eyes. MATERIAL AND METHODS: Twenty-eight patients with ocular hypertension, primary open angle, pseudoexfoliation or pigmentary glaucoma were enrolled. Following baseline measurements, latanoprost was applied topically once daily in the evening for 12 weeks. After a washout period, brimonidine was applied twice daily in all patients for six weeks; 16 patients continued for 12 weeks. Patients were examined at two, six, and 12 weeks. The primary outcome measure was the difference in mean intra ocular pressure (IOP) reduction at six and 12 weeks. The mean diurnal variation of IOP at baseline and at 12 weeks was also compared. RESULTS: Twenty-six of 28 enrolled patients completed the study. One randomly selected eye of each patient was used for analysis. At six weeks, the mean IOP reduction was 11.2 mmHg (± 2.9 mmHg) with latanoprost and 6 mmHg (± 3.3 mmHg) with brimonidine. At 12 weeks, this was 10.8 (± 2.8 mmHg) and 6.9 mmHg (± 3.1 mmHg), respectively. At six weeks, 85.7% (24) eyes obtained more than 25% reduction in IOP with latanoprost compared to 13 (46.4%) with brimonidine. IOP reduction was maintained with both drugs throughout the study period. Two eyes did not show any response to brimonidine. Latanoprost reduced the diurnal variation of IOP from 5.10-2.90 mmHg; brimonidine reduced it from 4.70-3.90 mmHg. Conjunctival hyperaemia was present in one patient on latanoprost and three patients on brimonidine. Two patients experienced drowsiness with brimonidine. Neither drug produced side effects necessitating withdrawal from the study. CONCLUSIONS: In this short-term study, both latanoprost and brimonidine effectively reduced IOP and stabilized the diurnal curve in Indian eyes. Latanoprost was more effective than brimonidine.
Dr. R. Thomas, LV Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad 500 034, India. ravithomas@lvpeye.stph.net
Classification:
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.4 Prostaglandins (Part of: 11 Medical treatment)
