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Abstract #8975 Published in IGR 5-2
Changes of nocturnal intraocular pressure and ocular blood flow following topical instillation of latanoprost
Nagumo H; Hagiwara N; Ito K; Oh G; Shibata S; Kishi SJapanese Journal of Clinical Ophthalmology 2003; 57: 483-485
Eight healthy volunteers received a single latanoprost instillation in one eye at 9 p.m. The authors measured the intraocular pressure (IOP), ocular perfusion pressure, and blood flow in the optic nervehead and the macula one, three, and six hours after instillation. The fellow eyes served as control. Ocular blood flow was measured using laser speckle flowgraphy. Square blur rate (SBR) served as an index of blood flow velocity. IOP decreased by 26% six hours after instillation. This decrease was beyond diurnal IOP fluctuation, but did not affect ocular perfusion pressure. There was no change in blood flow in the optic nerve head or macula. These findings show that topical latanoprost induced a hypotensive effect without affecting the blood flow in the optic nerve head. LA: Japanese
Dr. H. Nagumo, Department of Ophthalmology, Gunma University School of Medicine, 3-39-22 Showa machi, Maebashi-shi, Gunma-ken 371-8511, Japan
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
