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Abstract #8987 Published in IGR 5-2
Aqueous humour flow after a single oral dose of isosorbide-5-mononitrate in healthy volunteers
Kotikoski H; Oksala O; Vapaatalo H; Aine EActa Ophthalmologica Scandinavica 2003; 81: 355-360
PURPOSE: To investigate whether a nitric oxide donor given as a single oral dose is able to modify aqueous humor flow in healthy volunteers. METHODS: Ten healthy volunteers participated in a randomized, double-masked and placebo-controlled cross-over study. Aqueous humor flow was assessed by fluorophotometyr after intake of isosorbide-5-mononitrate (ISMN), 10 mg. Topical timolol maleate, which is known to reduce aqueous humor flow, was used as a positive control. Intraocular pressure (IOP) was measured by applanation tonometry and blood pressure was registered. RESULTS: The basal rate of aqueous humor flow did not change significantly after a single oral dose of ISMN. The aqueous humor flow in the timolol-treated eye was reduced compared to the contralateral eye (p = 0.002). Mean IOP six hours after placebo and ISMN intake did not differ significantly. Timolol lowered IOP by 4 mmHg (p < 0.001). ISMN did not lower systolic blood pressure, but diastolic blood pressure was reduced by 4 mmHg (p = 0.048). CONCLUSION: A single oral dose of 10 mg ISMN had no significant effect on aqueous humor flow in healthy volunteers.
Dr. H. Kotikoski, Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)