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Abstract #8990 Published in IGR 5-2
Switching from systemic to the topical carbonic anhydrase inhibitor dorzolamide: effect on the quality of life of glaucoma patients with drug-related side-effects
Nesher R; Ticho UIsraeli Medical Association Journal 2003; 5: 260-263
BACKGROUND: The frequent systemic side-effects associated with the use of systemic carbonic anhydrase inhibitors have adversely affected the compliance to treatment in glaucoma patients, obviating their long-term use. The introduction of the topical CAI dorzolamide has further reduced their use. However, the tolerability of dorzolamide in patients who have been intolerant to systemic CAIs has not been evaluated prospectively. OBJECTIVES: To study the tolerability and efficacy of dorzolamide (a topical CAI) in a selected group of glaucoma and ocular hypertensive patients who have been intolerant to systemic CAI. METHODS: A three-month prospective study was conducted in 39 patients. Following recruitment, patients were evaluated on the day of switching from systemic CAI to dorzolamide and for five more visits. The SF 36 health assessment questionnaire was used to evaluate changes in well being and quality of life, and the intraocular pressure (IOP) was measured periodically. RESULTS: Within four weeks of switching from systemic CAI to dorzolamide, the mean health assessment scores improved significantly in seven of the eight categories of the SF 36, and remained generally unchanged for the rest of the study. No significant differences were noted between mean IOP on day 0 and the following measurements throughout the 84 days of dorzolamide therapy. CONCLUSIONS: In glaucoma patients who were intolerant to systemic CAI, topical CAI dorzolamide offers a similar efficacy and better tolerability.
Dr. R. Nesher, Glaucoma Service, Department of Ophthalmology, Sapir Medical Center, Kfar Saba 44281, Israel. nesher@inter.net.il
Classification:
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
