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Abstract #8995 Published in IGR 5-2
Pulsatile ocular blood flow among normal subjects and patients with high tension glaucoma
Agarwal HC; Gupta V; Sihota R; Singh KIndian Journal of Ophthalmology 2003; 51: 133-138
PURPOSE: To estimate pulsatile ocular blood flow (POBF) in normal subjects and to compare various parameters in eyes with primary open-angle glaucoma (POAG) with high intraocular pressure (IOP). METHODS: POBF was estimated in 95 eyes of 95 normal subjects above the age of 40 years and in 35 eyes of 35 POAG patients using the OBF system (OBF Labs Ltd., UK). Correlation of age, gender, IOP, pulse amplitude, pulse volume and pulse rate with POBF was studied. POBF values were measured in glaucomatous patients before IOP control and one month later after control of IOP to < 22 mmHg. RESULTS: The mean POBF among normal subjects was 1382.2 ± 413 ml/min (range, 636-2291 ml/min). Females had a significantly higher mean POBF (1512 ± 347ml/min) than males (1193 ± 312ml/min). The mean IOP in normal subjects was 12.6 mmHg and in glaucoma patients, 29.1 mmHg. Mean POBF in glaucomatous eyes with initially elevated IOP was 718.9 ± 322.6 ml/min, which improved after IOP control to 1129 ± 291ml/min. IOP had a strong (p < 0.01) negative correlation with POBF (r = 0.667) CONCLUSIONS: CONCLUSIONS: POBF in eyes of normal subjects in this study is higher than that reported in Caucasian eyes. POAG eyes with high IOP have significantly reduced ocular blood flow. Therapy aimed at lowering IOP has a positive effect on ocular hemodynamics.
Dr. H.C. Agarwal, Dr. R.P. Centre for Ophthalmic Science, All India Institute of Medical Sciences, New Delhi 110 029, India. gupta_v@mailcity.com
Classification:
11.6 Osmotic treatment (Part of: 11 Medical treatment)
