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Abstract #90077 Published in IGR 21-3
Association Between Structure-function Characteristics and Visual Field Outcomes in Glaucoma Subjects With Intraocular Pressure Reduction After Trabeculectomy
Kadziauskienė A; Chua J; Baskaran M; Yow AP; Tan B; Sng C; Ašoklis R; Lesinskas E; Crowston J; Schmetterer L; Wong DWKJournal of Glaucoma 2020; 29: 648-655
PRECIS: Improvements in post-trabeculectomy visual field (VF) outcomes were found to be significantly associated with preoperative nerve fiber layer thickness parameters extracted from the sectorized structure-function relationship, baseline VF, and severity of glaucoma. OBJECTIVE: To determine whether the preoperative structure-function relationship helps to predict visual outcomes at 1-year post-trabeculectomy. PATIENTS AND METHODS: In total, 91 eyes from 87 participants who successfully underwent trabeculectomy were included in our study. All eyes received optical coherence tomography imaging and VF assessment using 30-2 standard automated perimetry preoperatively at baseline and postoperatively 1 year after trabeculectomy. The linear mixed-model analysis was used to assess the association of structure and function at baseline, and multivariate analysis to investigate factors associated with postoperative VF outcomes. RESULTS: Results from multivariate and univariate analysis for VF 1 year after trabeculectomy showed that a positive preoperative retinal nerve fiber layer thickness deviation from the structure-function model was found to be significantly associated with improved postoperative VF outcomes [β=0.06 dB/μm; 95% confidence interval (CI), 0.03-0.09]. Other significant factors included baseline VF MD (β=-0.18; 95% CI, -0.23 to -0.13) and the presence of severe glaucoma (β=-1.69; 95% CI, -2.80 to -0.57). Intraocular pressure was positively associated with improved VF outcomes only in univariate analysis (β=0.06; 95% CI, 0.01-0.11). CONCLUSIONS AND RELEVANCE: Characteristics derived from the baseline structure-function relationship were found to be strongly associated with postoperative VF outcomes. These findings suggest that the structure-function relationship could potentially have a role in predicting VF progression after trabeculectomy.
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Classification:
12.8.1 Without tube implant (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
13.2.2 Visual field (Part of: 13 Therapeutic prognosis and outcome > 13.2 Outcome)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
