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Abstract #9031 Published in IGR 5-2
Postoperative 5-fluorouracil versus intraoperative mitomycin C in high risk glaucoma filtering surgery: extended follow-up
Akarsu C; Önol M; Hasanreisoglu BClinical and Experimental Ophthalmology 2003; 31: 199-205
PURPOSE: To compare the long-term efficacy and safety of postoperative subconjunctival 5-fluorouracil (5-FU) injections with that of intraoperative mitomycin C (MMC) in eyes at high risk for failure of trabeculectomy. METHODS: In a retrospective, non-randomized comparative trial, 36 eyes of 36 consecutive patients at high risk for failure of trabeculectomy underwent glaucoma filtering surgery with either postoperative subconjunctival 5-FU injections (19 eyes) or intraoperative application of MMC (17 eyes). Intraocular pressure (IOP), number of postoperative antiglaucoma medications, postoperative visual acuity, interventions, and complications were evaluated. RESULTS: Overall success (IOP ≤ 21 mmHg) at one year was 73.6% in the 5-FU group and 82.3% in the MMC group. The cumulative four-year success rate was 52.6% in the 5-FU group and 60.5% in the MMC group (p = 0.6). At the four-year follow-up, mean ± SD IOP was 17.58 ± 4.01 mmHg in the 5-FU group and 13.33 ± 3.36 mmHg in the MMC group (p = 0.01). There was no significant difference in the number of postoperative medications (p = 0.84), appearance of blebs (p = 0.20), final visual acuity (p = 1.00), or complications (p > 0.05) between the groups. CONCLUSIONS: These results suggest that both postoperative 5-FU injections and intraoperative MMC application have long-term success in high risk patients. However, MMC results in a greater decrease in IOP than 5-FU.
Dr. C. Akarsu, Department of Ophthalmology, Suleyman Demirel Hospital, University of Kirikkale, Kirikkale 71100, Turkey. cengizakarsu@hotmail.com
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
