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Abstract #90371 Published in IGR 21-3
Analysis of Plasma Hydrogen Sulfide, Homocysteine, and L-Cysteine in Open-Angle Glaucoma Patients
Lin Z; Huang S; Yu H; Sun J; Huang P; Zhong YJournal of Ocular Pharmacology and Therapeutics 2020; 36: 649-657
To compare the plasma levels of hydrogen sulfide (HS), homocysteine (Hcy), and L-cysteine (Cys) among primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), ocular hypertension (OHT), and normal individuals. To explore associated factors and evaluate their diagnostic abilities in glaucoma. POAG, NTG, OHT, and normal subjects were recruited from Ruijin Hospital between December 2016 and December 2018. All subjects underwent thorough ophthalmological examinations, and fasting venous blood was taken to determine the concentrations of HS, Hcy, and Cys. Forty-two POAG, 20 NTG, 52 OHT, and 78 controls were enrolled. The HS levels in POAG group were significantly lower than those in OHT group ( = 0.036) and normal group ( < 0.001), while the Hcy and Cys levels in POAG and NTG groups were significantly higher ( = 0.007-0.043). The concentrations of HS, Hcy, and Cys in glaucoma patients with different stages were not significantly different (all > 0.05). POAG patients with longer duration of diagnosis had lower concentrations ( = 0.026, = 0.001, < 0.001), but no significant differences in NTG patients (all > 0.05). The Hcy and Cys levels in NTG patients showed negative but weak correlations with mean deviation ( = -0.450, = 0.047; = -0.478, = 0.033). All these concentrations showed significant but poor diagnostic values in POAG-Normal group [area under curve (AUC) = 0.642-0.721, < 0.05]. The HS level showed poor diagnostic power in POAG-OHT group (AUC = 0.657, < 0.01). Decreased levels of HS and increased levels of Hcy and Cys may be associated with glaucoma, especially in POAG. However, the HS/Hcy metabolic pathway is not sufficiently sensitive to be used as a reliable biomarker in glaucoma.
Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, China.
Full articleClassification:
3.7 Biochemistry (Part of: 3 Laboratory methods)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
