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BACKGROUND: Measurement of intraocular pressure (IOP) forms a crucial component in the diagnosis and management of glaucoma. Many devices have been developed to measure IOP with Goldmann applanation tonometry (GAT) considered the gold standard for IOP measurement. OBJECTIVES: The objective was to compare IOP measured using Icare ic100 and GAT. METHODS: This cross-sectional study measured IOP in1000 eyes (500 left, 500 right) using the ic100 and GAT. Central cornel thickness (CCT) was measured using a handheld pachymeter. IOP measurements were investigated in all eyes, by IOP sub-strata by CCT group, by number of topical glaucoma medications and diagnosis. RESULTS: There was moderate agreement between ic100 and GAT IOP measurements (intraclass correlation coefficient .73). Mean IOP was significantly lower measured by ic100 compared to GAT (12.1mmHg vs. 16.2mmHg, p<0.0001). Mean ic100 IOPs were also significantly lower than mean GAT IOPs within each IOP strata ≤12 (7.9mmHg vs. 9.7mmHg, p<0.0001) 13-21 (12.1mmHg vs. 16.6mmHg, p<0.0001) and ≥ 22 (18.4mmHg vs. 25.2mmHg, p<0.0001) and within each sub-analysis. CONCLUSIONS: The Icare ic100 tonometer consistently under-estimated IOP compared to GAT, irrespective of CCT ranges and other subgroup analyses. The mean difference of -4.2mmHg can have significant implications, particularly in the management of glaucoma patients.
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6.1.1 Devices, techniques (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)