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Abstract #90766 Published in IGR 21-3
Evaluation of bleb characteristics after trabeculectomy and glaucoma implant surgery in rabbit
Ishida K; Nakano Y; Ojino K; Shimazawa M; Otsuka T; Inagaki S; Kawase K; Hara H; Yamamoto TOphthalmic Research 2021; 64: 68-76
The characteristics of the conjunctival bleb are some of the most important factors for the surgical success of glaucoma filtering surgery. To improve surgical outcome, we investigated histology of bleb after three glaucoma surgeries. Surgery was performed in the 21 white rabbits. Rabbits were randomized and underwent trabeculectomy (TRAB), or implantation with EX-PRESS or a silicone tube (each n = 7). Bleb survival, intraocular pressure (IOP), and vascularity were evaluated. At 6 weeks, eyes were enucleated for histological analysis. Postoperative IOP at 2 weeks was significantly lower in the TRAB and EX-PRESS groups than in the tube group (p = 0.037), but not thereafter. Postoperative bleb survival (p = 0.542) and vascularity (p = 0.988) were similar among the 3 groups. Histologically, a capsule consisting of mild fibroblast proliferation associated with intercellular collagen was present around the surgical site. The thickness of the bleb was similar among all experimental groups, but was significantly greater than the control (p < 0.05). The inflammatory area did not differ between the EX-PRESS and tube groups, but was significantly greater in the TRAB group than that in the tube group (p = 0.031). The correlation between the thickness of bleb wall and inflammation was found in total (r=0.56, p < 0.01). EX-PRESS and a silicone tube implants appear to be relatively inert, with little difference in biocompatibility and bleb survival. Since some degree of inflammatory reaction was still observed by the histology of bleb, more non-invasive surgical methods and more biocompatible materials may be desirable.
Full article
Classification:
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
12.8.1 Without tube implant (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
12.8.2 With tube implant or other drainage devices (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
