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Abstract #90771 Published in IGR 21-3
Cognitive Impairment and Lamina Cribrosa Thickness in Primary Open-Angle Glaucoma
Lee SH; Han JW; Lee EJ; Kim TW; Kim H; Kim KWTranslational vision science & technology 2020; 9: 17
PURPOSE: The purpose of this study was to investigate the relationship between the lamina cribrosa (LC) thickness (LCT) as assessed using enhanced depth-imaging (EDI) optical coherence tomography (OCT) and cognitive function in primary open-angle glaucoma (POAG). METHODS: The study consisted of 105 POAG eyes and 23 nonglaucomatous control eyes that completed neuropsychological tests. The optic nerve heads of the patients were imaged using EDI-OCT. B-scan images were constructed in three dimensions using maximum intensity projection (MIP), and the LCT was measured using the thin-slab MIP images. A comprehensive battery consisting of 15 neuropsychological tests was used to evaluate cognitive function. RESULTS: POAG eyes had smaller mean LCT as compared with control eyes ( < 0.001). Age and Mini Mental State Examination (MMSE) scores did not differ between the two groups. Linear regression analysis revealed that lower scores on the MMSE ( < 0.001), presence of glaucoma ( = 0.006), and a smaller global retinal nerve fiber layer thickness ( < 0.001) were independently associated with a smaller mean LCT. Davies' test revealed a statistically significant breakpoint for the mean LCT (221.14 µm), below which a smaller MMSE score was significantly associated with a smaller mean LCT. In POAG eyes with a mean LCT smaller than the breakpoint (< 221.14 µm), not only the global cognition but also the visuospatial function and visual memory were worse than in those with a larger mean LCT (all ≤ 0.003). CONCLUSIONS: Impairment of cognitive function was observed in patients with POAG with a thinner LC. The role of LC imaging as a potential biomarker to monitor cognitive impairment needs further investigation. TRANSLATIONAL RELEVANCE: LC thinning may reflect a shared mechanism of neurodegenerative diseases in the brain and optic nerve.
Department of Ophthalmology, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, Korea.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
