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Abstract #91020 Published in IGR 21-4
Improvement in structure and visual function in patients with glaucoma: the possible key to better treatment?
Ahmed OM; Waisbourd M; Spaeth GL; Katz LJSurvey of Ophthalmology 2021; 66: 644-652
Glaucoma is characterized by retinal ganglion cell loss that can lead to permanent visual loss. Current clinical management practice assumes that glaucomatous visual loss is irreversible; however, there is increasing evidence that permanent vision loss and cell death are preceded by reversible functional and structural changes. We propose that these changes should be considered by glaucoma specialists when treating their patients. We discuss the neurobiological basis of this phenomenon and provide clinical evidence of reversibility in both structure and function. Specifically, we review the findings of visual field testing, contrast sensitivity, electroretinography, and imaging of the optic nerve and their correlation with functional changes. We then discuss the clinical value of these observations in helping guide approaches toward the diagnosis and treatment of patients with glaucoma.
Glaucoma Research Center, Wills Eye Hospital, Philadelphia, PA, USA; Yale University School of Medicine, New Haven, CT, USA.
Full articleClassification:
3.9 Pathophysiology (Part of: 3 Laboratory methods)
