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Abstract #91228 Published in IGR 21-4
Effect of intraocular pressure lowering on the capillary density of optic nerve head and retinal nerve fiber layer in patients with glaucoma
de Paula A; Perdicchi A; Di Tizio F; Fragiotta S; Scuderi GEuropean Journal of Ophthalmology 2020; 0: 1120672120967233
PURPOSE: To evaluate the effect of IOP lowering on the capillary density of optic nerve head and retinal nerve fiber layer in patients with primary open angle glaucoma. METHODS: Twenty eyes of 14 glaucomatous patients and 15 eyes of nine normal patients were enrolled. The most appropriate hypotonic treatment was applied to every patient. A HD Angio Disc 4.5 scan (Avanti-AngioVue) was performed at baseline and after a month in the glaucomatous eyes. The following parameters were analyzed: Radial Papillary Capillaries (RPC) density, inside disc, peripapillary, superior-hemi, inferior-hemi, quadrants, and peripapillary, hemi-superior, hemi-inferior, and quadrants RNFL thickness. Optic nerve head analysis was also evaluated. In addition, the RPC density and the RNFL were assessed in the eight sectors provided by the software. RESULTS: The RPC density did not significantly change after IOP reduction ( > 0.05). The inferior-temporal ( = 0.005) and inferior-nasal sectors ( < 0.001) showed a greater capillary density than the respective superior sectors in healthy eyes. In contrast in the glaucomatous eyes, the superior-nasal exhibited greater capillary density with respect to the inferior-nasal sectors. The aggregate RPC density of the inferior sectors was greater than the superior ones in the control group ( < 0.001). An improvement of the average disc area ( = 0.01) and the average cup volume ( = 0.059) were also observed along with increased RNFL thickness at different locations (all, < 0.05) after IOP lowering therapy was initiated. CONCLUSION: The glaucomatous eyes presented rarefaction of the radial papillary capillaries density in the inferior sectors, but no significant changes in the density after IOP-lowering medications.
Ophthalmology Unit, NESMOS Department, St. Andrea Hospital, University of Rome "La Sapienza," Rome, Italy.
Full articleClassification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)