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Abstract #91335 Published in IGR 21-4
A software for quantification of vessel density in glaucoma: An OCT-Angiography study
Miguel A; Miguel A; Legeai J; Silva BJournal Français d'Ophtalmologie 2021; 44: 376-381
PURPOSE: To assess the capillary vessel density in the peripapillary region of glaucoma patients in comparison to controls using automated software. METHODS: We performed an observational, cross-sectional case-control study with 72 eyes of glaucoma patients (with strict selection criteria) and 30 age-matched healthy controls. We used an optical coherence tomography angiography device (Triton, Topcon) with scans of 4.5×4.5mm centered on the optic nerve head, excluding images of poor quality. Since this device does not quantify vessel density, we wrote software (with Visual Studio©) that allowed us to remove large blood vessels and quantify the capillary density in the peripapillary region. We tested the ability of OCT-A to differentiate glaucoma from controls using the receiver operating characteristic curve (ROC). We also verified whether VD was correlated with visual field mean deviation. RESULTS: VD was significantly lower in glaucoma than in controls, notably the whole-image VD of 72.45±7.45% in glaucoma and 77.87±3.77% in controls (P<0.001). VD values were correlated with visual fields (Spearman correlation of 0.33; P 0.0017). ROC was moderate (color VD of 0.629±0.143), but better than that of the visual field (0.229±0.077) or the retinal nerve fiber layer thickness assessed by OCT (0.326±0.064). CONCLUSIONS: This software is useful for quantifying vessel density at the optic disc, peripapillary and capillary levels and for documenting glaucomatous changes in vascularization. OCT-A might be useful in diagnosis of glaucoma.
Center for Research in Health Technologies, Information Systems (CINTESIS), Department of Health Information, Decision Sciences, Faculty of Medicine, University of Porto, Portugal; Department of Ophthalmology, Polyclinique de la Baie, Vivalto Sante, Avranches, France. Electronic address: myworld_ana@hotmail.com.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)