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Abstract #92078 Published in IGR 22-1
Investigation of the Peripapillary Choriocapillaris in Normal Tension Glaucoma, Primary Open Angle Glaucoma, and Control Eyes
Bhalla M; Heisler M; Mammo Z; Ju MJ; Sarunic MV; Navajas EV; Warner S; Schendel S; Gill KSJournal of Glaucoma 2021; 30: 682-689
PRCIS: The peripapillary choriocapillaris was observed to be significantly impaired in normal tension glaucoma subjects compared to normal controls using OCT Angiography. PURPOSE: To quantitatively evaluate the peripapillary choriocapillaris in normal tension glaucoma (NTG), primary open angle glaucoma (POAG) and control eyes using optical coherence tomography angiography (OCTA). METHODS: Ninety eyes (30 controls, 30 NTG, and 30 POAG) from 73 patients were imaged using the Zeiss Plex Elite 9000. Five repeat 3×3▒mm OCTA scans were acquired both nasally and temporally to the optic disc and subsequently averaged. Four choriocapillaris flow deficit (FD) measures were calculated using the fuzzy C-means approach: FD density (FDD), mean FD size (MFDS), FD number (FDN), and FD area (FDA). RESULTS: Temporal NTG choriocapillaris parameters were associated with visual field index and mean deviation (P<0.05). The control group showed a significantly lower nasal FDD (Nasal: 3.79±1.26%, Temporal: 4.48±1.73%, P=0.03), FDN (Nasal: 156.43±38.44, Temporal: 178.40±45.68, P=0.02), and FDA (Nasal: 0.22±0.08, Temporal 0.26±0.10, P=0.03) when compared to temporal optic disc. The NTG group showed a significantly higher FDD (NTG: 5.04±2.38%, Control: 3.79±1.26%, P=0.03), FDN (NTG: 185.90±56.66, Control: 156.43±38.44, P=0.04), and FDA (NTG: 0.30±0.14▒mm2, Control: 0.22±0.08▒mm2, P=0.03) nasal to the optic disc compared to controls. CONCLUSIONS: Association between choriocapillaris parameters and glaucoma severity in NTG, but not POAG subjects, suggests vascular abnormalities may be a potential factor in the multifactorial process of glaucoma damage in NTG patients.
Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada School of Engineering Science, Simon Fraser University, Burnaby, British Columbia, Canada Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada.
Full articleClassification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)