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PRECIS: CMvD is an independet predictor for overall and central visual field progression in OAG eyes. PURPOSE: To investigate the impact of choroidal microvasculature dropout (CMvD) identified by optical coherence tomography angiography (OCT-A) at baseline on subsequent visual field (VF) progression in eyes with open-angle glaucoma (OAG). MATERIALS AND METHODS: This retrospective observational study included 80 OAG eyes with CMvD [CMvD(+)] and without CMvD [(CMvD(-)] at baseline (40 of each matched for both age [≤ 10▒y] and baseline VF severity [≤ 1▒dB]). Subjects were followed regularly at 6-month intervals. VF progression was defined according to the Early Manifest Glaucoma Trial criteria. The associations of overall VF progression with baseline clinical factors, including the presence of CMvD and other variables, were analyzed by logistic regression with a generalized estimating equation (GEE) in the entire OAG cohort. Linear mixed models were used to determine the differences in VF mean sensitivity (VFMS) between the CMvD(+) and CMvD(-) groups globally and regionally at each follow-up point. RESULTS: During a mean follow-up of 35.91 ± 2.51 months, a significant difference was evident in the VF progression rate between the CMvD(-) and CMvD(+) groups (22.5% vs. 70%, P < 0.001). CMvD at baseline and a higher visit-to-visit intraocular pressure (IOP) fluctuation were significant predictors of VF progression. The VFMS differed significantly between the two groups at the central and superior central VF regions after 2 years of follow-up. CONCLUSION: The presence of CMvD at baseline is an independent predictor of subsequent VF progression. CMvD(+) eyes show a faster rate of VFMS loss at the central and superior central VF region.
Department of Ophthalmology, Konkuk University Medical Center, Seoul, Korea Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
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6.20 Progression (Part of: 6 Clinical examination methods)
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