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Abstract #92763 Published in IGR 22-1
Association Between Serum Lipid Levels and Patients With Primary Angle-Closure Glaucoma in China: A Cross Sectional, Case-Control Study
Shao M; Li Y; Teng J; Li S; Cao WFrontiers in medicine 2021; 8: 618970
To evaluate the serum lipid levels of patients with primary angle-closure glaucoma (PACG) and to investigate the relationship between serum lipid levels and PACG. In this cross-sectional, case-control study, a total of 320 PACG subjects and 242 age- and sex-matched control subjects were recruited. Serum high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (SDLDL-C), triglyceride (TRIG), and cholesterol (CHOL) levels were measured using enzymatic colorimetry. Serum apolipoprotein A (APOA), apolipoprotein B (APOB), apolipoprotein E (APOE), and lipoprotein(a) (LPa) levels were measured by immunoturbidimetry. The serum LDL-C, TRIG, HDL-C, APOE, LPa, CHOL, APOB, and APOA levels were significantly higher ( < 0.05) in the PACG group than in the control group. Multiple liner regression analyses revealed that there was a statistically correlation between HDL-C levels and mean deviation MD ( = 0.389, = 0.002, 95% confidence interval [CI] = -1.249 to -0.624); LDL-C levels and MD ( = 0.190, = 0.019, 95% CI = -5.632 to -1.306); and CHOL levels and MD ( = 0.364, = 0.27, 95% CI = -7.727 to -1.839). Logistic regression analyses showed that high serum HDL-C (odds ratio [OR] = 11.01, 95% CI = 5.616-21.587), LDL-C (OR = 1.330, 95% CI = 1.079-1.640), SDLDL-C (OR = 1.007, 95% CI = 1.005-1.008), APOA (OR = 13.621, 95% CI = 7.251-25.591), APOB (OR = 2.243, 95% CI = 1.060-4.732), LPa (OR = 0.999, 95% CI = 0.998-1.00), and CHOL (OR = 1.131, 95% CI = 1.005-1.326) levels were significantly associated with PACG. High serum HDL-C, LDL-C, APOA, APOB, LPa, and CHOL levels were associated with PACG.
Clinical Laboratory, Eye & Ear Nose Throat (ENT) Hospital, Fudan University, Shanghai, China.
Full articleClassification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
3.7 Biochemistry (Part of: 3 Laboratory methods)
