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Abstract #94678 Published in IGR 22-2
Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma
Zhou X; Zhou YN; Ali A; Liang C; Ye Z; Chen X; Deng L; Sun X; Zhang Q; Luo J; Li W; Zhou K; Cao S; Zhang X; Li XD; Zhang XE; Cui Z; Men DFrontiers in immunology 2021; 12: 701295
The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.
Hubei Province Hospital of Traditional Chinese Medicine, Wuhan, China.
Full articleClassification:
15 Miscellaneous
3.10 Immunobiology (Part of: 3 Laboratory methods)
