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Abstract #94859 Published in IGR 22-2
Optical microangiography and progressive retinal nerve fiber layer loss in primary open angle glaucoma
Rao HL; Dasari S; Puttaiah NK; Pradhan ZS; Moghimi S; Mansouri K; Webers CA; Weinreb RNAmerican Journal of Ophthalmology 2022; 233: 171-179
PURPOSE: To evaluate the association between optical microangiography (OMAG) measurements and progressive retinal nerve fiber layer (RNFL) loss in primary open angle glaucoma (POAG). DESIGN: Prospective case series METHODS: Sixty-four eyes of 40 POAG patients (108 quadrants) with mild to moderate functional damage were longitudinally studied for at least 2 years and with a minimum of 3 optical coherence tomography (OCT) examinations. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, gender, presence of systemic diseases, central corneal thickness, presence of disc hemorrhage, mean and fluctuation of intraocular pressure during follow-up), baseline hemifield mean deviation (MD), baseline quadrant OCT (retinal nerve fiber layer [RNFL] and ganglion cell inner plexiform layer [GCIPL] thickness) and OMAG (peripapillary and macular perfusion density [PD] and vessel density [VD]) on the rate of RNFL change was evaluated using linear mixed models. RESULTS: Average (±SD) MD, RNFL and GCIPL thickness of the analyzed quadrants at baseline were -5.5±2.9 dB, 96.5±17.9 µm, and 73.8±8.6 µm, respectively. Peripapillary PD and VD in the quadrant were 44.6±5.9% and 17.5±2.2 mm/mm respectively. Rate of quadrant RNFL change was -1.8±0.6 µm/year. Multivariate mixed models showed that lower peripapillary PD (coefficient: 0.08, p=0.01) and lower VD (coefficient: 0.21, p=0.02) were significantly associated with faster rate of RNFL loss. CONCLUSIONS: Lower baseline peripapillary PD and VD measured using OMAG were significantly associated with a faster rate of RNFL loss in POAG. OMAG imaging provides useful information about the risk of glaucoma progression and the rate of disease worsening.
Narayana Nethralaya, 63, Bannerghatta Road, Hulimavu, Bangalore 560076, India; University Eye Clinic Maastricht, University Medical Center, Maastricht, the Netherlands. Electronic address: harshalaxmanarao@gmail.com.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)