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Abstract #94907 Published in IGR 22-2
The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma
Himori N; Inoue Yanagimachi M; Omodaka K; Shiga Y; Tsuda S; Kunikata H; Nakazawa TClinical Ophthalmology 2021; 15: 2293-2300
PURPOSE: Oxidative stress may be a risk factor for glaucoma, and many previous reports have suggested that antioxidants could be a promising treatment. Here, we investigated the effects of a novel supplement containing three food-derived antioxidants (hesperidin, crocetin, and ) on markers of oxidative stress in patients with glaucoma. PATIENTS AND METHODS: This study had a prospective, single arm design. Thirty Japanese glaucoma patients were recruited and given 4 tablets with ample water twice a day for 8 weeks. The treatment was stopped, and the subjects were followed for an additional 8 weeks. We measured biological antioxidant potential (BAP) with a free radical analyzer. We also measured urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG; a marker of oxidative DNA damage). Clinical laboratory data were measured in venous blood samples. Clinical parameters were also recorded. Comparisons used a one-way analysis of variance (ANOVA) followed by Dunnett's test. RESULTS: The 8-OHdG level was not reduced. We also divided the patients into groups with high or low oxidative stress. In patients with relatively high oxidative stress, the 8-OHdG level was significantly reduced at weeks 4, 8, 12, and 16 ( < 0.001, < 0.01, < 0.01, < 0.01), and BAP was significantly elevated at weeks 8 and 12 ( = 0.03, = 0.04). In patients with relatively low oxidative stress, the 8-OHdG level was not significantly reduced during supplement intake but was significantly elevated at weeks 12 and 16 ( =0.03, = 0.04), while BAP was not significantly elevated. CONCLUSION: An 8-week oral course of antioxidant supplementation was effective in patients with a high oxidative stress level. Dietary supplementation could hold promise in the treatment of systemic oxidative stress-related diseases.
Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
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