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Abstract #95110 Published in IGR 22-2
Corneal Crosslinking Biomechanics Evaluated by a Novel and Easily Implemented Differential Tonometry Method
Wang M; Berdahl J; McCafferty SCurrent Eye Research 2021; 46: 1614-1620
: Evaluate potential corneal biomechanical changes following corneal crosslinking (CXL) by paired differential tonometry intraocular pressure (IOP) measurements with a Goldmann tonometer (GAT) prism and corneal compensating, correcting applanation tonometry surface (CATS) prism.: IOP was measured prospectively on 23 unique eyes undergoing CXL for keratoconus with a GAT using a standard flat GAT prism and a curved corneal error correcting CATS prism before treatment and at 2 weeks, 2 months and 6 months after treatment. Concurrent measurements of central corneal thickness (CCT) and corneal hysteresis (CH) were completed.: Paired IOP measurements with standard GAT and corneal correcting CATS prisms indicated a significant sustained relative increase in the differential IOP between the two prisms after CXL ( = .002,0.051,0.062). CH initially decreased at two weeks post-CXL then returned to sustained pre-op levels ( = .033,0.20,0.20). CCT progressively decreased following CXL ( = .005).: Differential tonometry between standard GAT and corneal biomechanical compensating CATS prisms indicates findings consistent with increased corneal rigidity following CXL and may demonstrate a simple and sensitive method for measurement of relative corneal biomechanical changes due to pharmacologic agents and procedures.
Ophthalmology, Cornea Associates, Tucson, Arizona, USA.
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