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Abstract #95391 Published in IGR 22-2
The Spectrum of Ocular Manifestations in Patients with Waldenström's Macroglobulinemia
Dammacco R; Lisch W; Kivelä TT; Terpos E; Kastritis E; Sisto D; Mavilio A; Ria R; Alessio G; Vacca A; Dammacco FOcular Immunology and Inflammation 2021; 0: 1-10
: To investigate the ocular manifestations in 91 Waldenström's macroglobulinemia (WM) patients.: Retrospective, cross-sectional, observational analysis.: Ocular impairments, detected in 19 patients, included flame-shaped hemorrhages, venous sausaging, papilledema, macular detachments, or central retinal vein occlusion in 16 patients; paraproteinemic keratopathy in 2; and a CANOMAD syndrome in 1. Best-corrected visual acuity was ≥0.5 logMAR units in 11 of 38 eyes. Intraocular pressure was increased in seven eyes. Genetic analysis in seven patients showed a mutation in the MYD88 gene in six patients and a nonsense mutation in the CXCR4 gene in five patients. Plasmapheresis followed by chemotherapy with or without the addition of rituximab resulted in improvement or normalization of the ophthalmological findings in 15 patients.: The ocular manifestations of WM are protean and potentially sight threatening. Recent advances in genomic profiling and chemotherapy have remarkably improved the hematological and ophthalmological outcomes of these patients.
Department of Ophthalmology and Neuroscience, University of Bari "Aldo Moro", Medical School, Bari, Italy.
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