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Abstract #95651 Published in IGR 22-3
Circulating fatty acids and risk of primary open-angle glaucoma: A mendelian randomization study
Bao J; Yang Z; Zheng S; Li J; Shentu XGene 2022; 811: 146078
PURPOSE: The relationship between fatty acids (FAs) and glaucoma remains controversial despite several observational studies. We organized a mendelian randomization (MR) study to determine the genetic causal association between circulating FAs and primary open-angle glaucoma (POAG). METHODS: The two-sample MR method was used to acquire causal estimates. Fourteen distinct single nucleotide polymorphisms (SNPs) of ten FAs were chosen as instrumental variables (IVs) at a genome-wide significance level (p < 5 × 10). SUMMARY: statistics for POAG were available from a genome-wide association meta-analysis of 216,257 individuals of European ancestry (16,677 cases, 199,580 controls). The inverse-variance weighted (IVW) method was adopted to evaluate the causality of FAs and POAG. Multiple sensitivity analyses were applied to avoid pleiotropy. RESULTS: The IVW method suggested no evidence to support causal effects of ten FAs on POAG. The odds ratio (OR) per one SD increment of each FA was OR = 1.64 (95% CI, 0.441-6.098, p = 0.46), OR = 0.815 (95% CI, 0.604-1.101, p = 0.182), OR = 0.896 (95% CI, 0.669-1.198, p = 0.458), OR = 1.014 (95% CI, 0.801-1.283, p = 0.91), OR = 1.008 (95% CI, 0.971-1.045, p = 0.683), OR = 0.993 (95% CI, 0.973-1.013, p = 0.483), OR = 0.731 (95% CI, 0.261-2.048, p = 0.551), OR = 1.048 (95% CI, 0.934-1.175, p = 0.425), OR = 1.039 (95% CI, 0.903-1.196, p = 0.593), OR = 0.967 (95% CI, 0.879-1.062, p = 0.477). Moreover, Sensitivity analysis indicated no pleiotropy. CONCLUSION: This MR study does not support causal associations between ten FAs and POAG.
Department of Ophthalmology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, Zhejiang, China.
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