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Abstract #95806 Published in IGR 22-3
Glaucoma Is Not Associated With Alzheimer's Disease or Dementia: A Meta-Analysis of Cohort Studies
Zhao W; Lv X; Wu G; Zhou X; Tian H; Qu X; Sun H; He Y; Zhang Y; Wang C; Tian JFrontiers in medicine 2021; 8: 688551
Previous studies evaluating the relationships of glaucoma with Alzheimer's disease (AD) and dementia showed inconsistent results. We performed a meta-analysis of cohort studies to evaluate the association between glaucoma with incidence of AD, all-cause dementia, and non-AD dementia. Cohort studies which evaluated the association between glaucoma with incidence of AD, all-cause dementia, and non-AD dementia in adult population with multivariate analyses were identified by systematic search of PubMed, Embase, and Cochrane's Library databases. A random-effects model incorporating the potential intra-study heterogeneity was used for the meta-analysis. Eleven cohort studies including 4,645,925 participants were included. RESULTS: showed that compared to those without glaucoma at baseline, adult patients with glaucoma was not independently associated with increased incidence of AD [adjusted risk ratio (RR): 1.03, 95% confidence interval (CI): 0.93-1.05, = 0.55; = 83%], all-cause dementia (adjusted RR: 1.08, 95% CI: 0.97-1.19, = 0.15; = 79%), or non-AD dementia (adjusted RR: 1.05 95% CI: 0.91-1.21, = 0.49; = 82%). Sensitivity analyses by excluding one study at a time did not significantly affect the results of the meta-analyses. Moreover, subgroup analyses showed consistent results in meta-analysis of prospective or retrospective cohort studies, and in meta-analysis of patients with primary open-angle glaucoma or primary angle-closure glaucoma (-values for subgroup difference all > 0.05). Current evidence from cohort studies did not support that glaucoma is an independent risk factor of AD, all-cause dementia, or non-AD dementia in adult population.
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