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Abstract #95886 Published in IGR 22-3
Multilayer Macula Vessel Density and Visual Field Progression in Glaucoma
Kamalipour A; Moghimi S; Hou H; Hou H; Hou H; Proudfoot JA; Nishida T; Zangwill LM; Weinreb RNAmerican Journal of Ophthalmology 2022; 237: 193-203
PURPOSE: To evaluate the association of macular superficial vessel density (SVD) and projection-resolved deep vessel density (DVD) with past visual field (VF) progression in primary open angle glaucoma patients. DESIGN: Retrospective cohort MATERIALS AND METHODS: In this longitudinal study, 208 eyes of 147 glaucoma patients from the Diagnostics Innovations in Glaucoma Study were included. Eligible participants were required to have at least five 24-2 VF tests over a minimum follow-up period of 3 years prior to macular optical coherence tomography angiography (OCTA) imaging. Visual field progression was defined based on both event-based pointwise linear regression (PLR) and trend-based methods. The association of macular SVD and DVD with the probability and rate of past VF progression was evaluated using linear mixed effects model. RESULTS: Fifty-two (25%) eyes had VF progression based on the PLR based criterion at the end of a mean (±SD) follow-up duration of 6.9 (±1.2) years. In the event-based multivariable analysis, lower baseline SVD was associated with a higher likelihood of past VF progression (OR per 1% lower = 1.28, 95% CI: 1.02, 1.59). Similarly, in the trend-based multivariable analysis, lower macular SVD was associated with a faster past rate of mean deviation decline (coefficient = -0.03 dB/year; 95% CI: -0.04, -0.01). Event-based and trend-based analyses found no significant associations for macular DVD with the likelihood/rate of past VF progression (P>0.05). CONCLUSIONS: Lower macular SVD, and not DVD, was associated with a higher probability of past VF progression. Macular OCTA imaging shows promise for identifying eyes at risk of VF progression in glaucoma patients.
Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA.
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