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Abstract #96028 Published in IGR 22-3
Myopic Open-Angle Glaucoma Prevalence in Northeast Asia: A Systematic Review and Meta-Analysis of Population-Based Studies
Jeong Y; Ha A; Shim SR; Kim YKKorean Journal of Ophthalmology 2022; 36: 6-15
PURPOSE: Investigation of myopic open-angle glaucoma (OAG) prevalence in Northeast Asia by systematic review and meta-analysis. METHODS: Systematic PubMed, EMBASE and Cochrane database searches for Northeast Asian population-based studies published up to 30 November 2020 and reporting on myopia and OAG diagnosis. By random-effect models, pooled OAG prevalence in a myopic population and pooled myopic OAG prevalence in a general population were generated, with 95% confidence intervals (CIs). RESULTS: The meta-analysis encompassed 5 population-based studies in 4 countries (12,830 individuals, including 7,723 patients with myopia and 1,112 patients with OAG). In a myopic population, OAG prevalence was 4.10% (95% CI, 3.00-5.70; I2 = 93%); in a general population, myopic OAG prevalence was 1.10% (95% CI, 0.60-1.70; I2 = 94%). A visual examination of funnel plot symmetry raised a suspicion of publication bias. Notwithstanding, Begg and Mazumbar's adjusted rank correlation test showed no such evidence (P = 0.6242). CONCLUSIONS: Our systematic review and meta-analysis returned an estimate of OAG prevalence in a myopic Northeast Asian population. Our findings will inform future glaucoma studies as well as public health guidelines for Northeast Asian populations.
Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
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