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Abstract #9690 Published in IGR 5-3
NMDA-induced neuron damage of retinal ganglion cell layer in rat
Shi J; Jiang Y; Liu XChinese Ophthalmic Research 2003; 21: 471-473
OBJECTIVE: To investigate the neurotoxic effect of N-methyl-D-aspartate on neurons of retinal ganglion cell layer in rat. METHODS: The right eyes of rats were given intravitreal injections with different dosage of N-methyl-D-aspartate (NMDA). Neuron counting of RGCL was performed to evaluate neuron loss at different survival time after intervention. RESULTS: There was dose- and time-related loss of neurons in retinal ganglion cell layer(RGCL) after NMDA intravitreal injection. Neurons with large diameter were the most sensitive to NMDA-mediated excitotoxity (p < 0.05). CONCLUSIONS: NMDA excitoxcity could induce the neuron damage in RGCL. The large neurons are predominately sensitive to the damage. It is similar to the pattern of neuron damage seen in glaucomatous optic neuropathy. The authors suggest that the model referred to above could be used to study glaucomatous optic nerve damage. LA: Chinese
Dr. J. Shi, Second Xiangya Hospital, Central-South University, Changsha 410011, China
Classification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
3.6 Cellular biology (Part of: 3 Laboratory methods)
3.9 Pathophysiology (Part of: 3 Laboratory methods)
