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Abstract #9726 Published in IGR 5-3
Latanoprost in port wine stain related paediatric glaucoma
Ong T; Chia A; Nischal KKBritish Journal of Ophthalmology 2003; 87: 1091-1093
AIM: To evaluate the efficacy of latanoprost (Xalatan) as adjunctive therapy in port wine stain related paediatric glaucoma. METHODS: A retrospective non-randomized study. Patients with previous surgical intervention and medical treatment were included. Measurements were recorded from clinic and/or examination under anesthetic (EUA) visits. A successful outcome was considered to be patients who required no further intervention following initiation of latanoprost, with stable glaucoma factors as well as drop in intraocular pressure. RESULTS: Fourteen patients and 17 eyes were reviewed in total. The mean age of glaucoma diagnosis was 2.59 years (0.1-5.25 years) and of commencing latanoprost was 6.8 years (1.40-12.90 years). Percentage success at one, three and six months, and one year was 70.6, 64.7, 58.9, and 47.1%, respectively, of eyes treated, which translated to 71.4, 64.2, 57.1, and 50%, respectively, of patients treated. CONCLUSIONS: A trial of latanoprost as adjunctive therapy in patients with port wine stain related glaucoma may temporise the need for surgery; with 50% of patients being controlled at the one-year follow-up. Lack of efficacy was detected as early as one month following commencement of treatment.
Dr. T. Ong, Department of Ophthalmology, Great Ormond Street Hospital for Children, London, UK
Classification:
9.4.9 Glaucomas associated with elevated episcleral venous pressure (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
11.4 Prostaglandins (Part of: 11 Medical treatment)
