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Abstract #9728 Published in IGR 5-3
Twenty-four-hour pattern of mouse intraocular pressure
Aihara M; Lindsey JD; Weinreb RNExperimental Eye Research 2003; 77: 681-686
The 24-hour pattern of intraocular pressure (IOP) in the mouse eye remains poorly characterized. The present study was undertaken to determine the magnitude, dynamic pattern, and synchrony of the 24-hour pattern of IOP in NIH Swiss mice exposed to a 12-hour light/dark cycle or to constant light. IOP was measured every three hours using a microneedle method. Mice exposed to a 12-hour light /dark cycle were either measured repeatedly at one week intervals (group 1) or were only measured once (group 2). A third group was exposed to constant light for two weeks prior to IOP measurements. The 24-hour IOP pattern in the first and second groups showed a similar rhythmic pattern that appeared to be sinusoidal. This IOP pattern declined in the morning until 12:00, and then increased in the early evening until 21:00. In contrast, IOP in the third group was asynchronous with some mice exhibiting multiple peaks and troughs during the 24-hour period. These results show that 24-hour IOP pattern in mouse eyes is biphasic and that extended exposure to constant light disrupts this 24-hour IOP pattern.
Classification:
5 Experimental glaucoma; animal models
6.1 Intraocular pressure measurement; factors affecting IOP (Part of: 6 Clinical examination methods)
