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Abstract #9747 Published in IGR 5-3
Nocturnal elevation of intraocular pressure is detectable in the sitting position
Liu JHK; Bouligny RP; Kripke DF; Weinreb RNInvestigative Ophthalmology and Visual Science 2003; 44: 4439-4442
PURPOSE: When intraocular pressure (IOP) was monitored in supine healthy young adults throughout a 24-hour period, a diurnal-to-nocturnal elevation of IOP was observed. This study was undertaken to investigate whether a similar elevation of IOP can be detected when experimental subjects are in the sitting position. METHODS: Experimental subjects were 16 nonsmoking, healthy young volunteers (aged, 18-25 years). Subjects with myopia of more than 3 D were excluded. They were housed in a sleep laboratory for 24 hours in a strictly controlled environment. An eight-hour nocturnal/sleep period was assigned to each volunteer according to the individual's accustomed sleep cycle. IOP was measured every two hours with a pneumatonometer with the volunteers in both sitting and supine positions. Mean diurnal-to-nocturnal IOP change and the cosine-fit 24-hour IOP rhythm were compared between the sitting and the supine IOP data. RESULTS: Mean IOP was significantly higher in the nocturnal period than in the diurnal/wake period for both the sitting and the supine IOP. The 24-hour IOP troughs appeared at the end of the diurnal period, and the peaks appeared at the end of the nocturnal period. The difference between the trough and the peak was 3.8 ± 0.6 mmHg (mean ± SEM) in the sitting position and 3.4 ± 0.6 mmHg in the supine position. Cosine-fitting of 24-hour IOP data showed a synchronized 24-hour rhythm of the sitting and the supine IOP for the group. There was no difference in the phase timing or the magnitude of variation between these two 24-hour rhythms of sitting and supine IOP. CONCLUSIONS: A nocturnal elevation of IOP can be detected in healthy young adults in both the sitting and the supine positions. There is a 24-hour rhythm of sitting IOP that is not different from the 24-hour rhythm of supine IOP.
Dr. J.H. Liu, Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, CA 92093, USA. joliu@ucsd.edu
Classification:
6.1 Intraocular pressure measurement; factors affecting IOP (Part of: 6 Clinical examination methods)
