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Abstract #9749 Published in IGR 5-3
Laboratory assessment of diurnal and nocturnal ocular perfusion pressures in humans
Liu JHK; Gokhale PA; Loving RT; Kripke DF; Weinreb RNJournal of Ocular Pharmacology and Therapeutics 2003; 19: 291-297
The authors estimated diurnal and nocturnal levels of ocular perfusion pressure at rest in both young and older adults in a clinical sleep laboratory. Measurements of blood pressure and intraocular pressure (IOP) were obtained every two hours for 24 consecutive hours in 16 healthy young adults (aged 18-25 years) and 16 older adults (aged 47-74 years). In the 16-hour diurnal wake period, blood pressure and IOP were measured after a five-minute sitting rest. In the eight-hour nocturnal period, measurements were taken with subjects in the supine position. Sitting and supine ocular perfusion pressures in the diurnal and nocturnal periods were calculated respectively based upon the blood pressure and IOP. Ocular perfusion pressure was found to be higher in the older group than in the younger group throughout the 24 hours. The peak of ocular perfusion pressure was in the nocturnal period for both groups. Within each subject group, the average nocturnal ocular perfusion pressure in the supine position was higher than the average diurnal ocular perfusion pressure in the sitting position. The diurnal-to-nocturnal increase of ocular perfusion pressure was larger in the older group than in the younger group.
Dr. J.H.K. Liu, University of California, San Diego, Department of Ophthalmology, 9500 Gilman Drive, San Diego, CA 92093-0946, USA
Classification:
6.1 Intraocular pressure measurement; factors affecting IOP (Part of: 6 Clinical examination methods)
