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Abstract #98757 Published in IGR 22-4
Long-term Evolution of Estimated Glomerular Filtration Rate in Patients With Antiviral Treatment for Hepatitis C Virus Infection
Liu CH; Lin JW; Liu CJ; Su TH; Wu JH; Tseng TC; Chen PJ; Kao JHClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023; 21: 424-434.e5
BACKGROUND & AIMS: Data regarding the long-term evolution of estimated glomerular filtration rate (eGFR) in patients receiving antiviral treatment for hepatitis C virus are limited. METHODS: A total of 1987 patients with eGFR ≥15 mL/min/1.73m who received interferon or direct-acting antiviral treatment were prospectively enrolled in this cohort study. The eGFR was assessed biannually by the Chronic Kidney Disease Epidemiology Collaboration equation from the time point of sustained virologic response (SVR). Multivariate generalized estimated equation was used to assess the association between the factors of interest and evolution of eGFR following antiviral treatment. Multivariate Cox regression analysis was used to assess the relative risk of end-stage renal disease (ESRD), defined as an eGFR <15 mL/min/1.73m. RESULTS: Patients who achieved SVR (adjusted slope coefficient difference: 2.36 mL/min/1.73 m/year; 95% confidence interval [CI], 1.50 to 3.32; P < .001) were associated with eGFR improvement, compared with those who did not achieve SVR. Among patients who achieved SVR, the eGFR evolution was comparable (adjusted slope coefficient difference: 0.31 mL/min/1.73m/year; 95% CI, -0.34 to 0.96; P = .35) in those treated with interferon or direct-acting antiviral. The incidence rates of ESRD in patients who achieved and did not achieve SVR were 0.06 per 100 person-years and 0.37 per 100 person-years. Patients who achieved SVR were associated with a lower risk of ESRD (adjusted hazard ratio, 0.24; 95% CI, 0.05-0.68; P = .021). CONCLUSIONS: The long-term eGFR evolution and risk of ESRD are significantly improved in patients who achieve SVR with anti- hepatitis C virus treatment.
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Douliou, Taiwan.
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