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Abstract #98761 Published in IGR 22-4
Glaucoma Cascade Screening in a High-risk Afro-Caribbean Haitian Population: A Pilot Study
Chang TC; Celestin L; Hodapp EA; Grajewski AL; Junk A; Rothman AL; Duerr ERH; Swaminathan SS; Gedde SJ; Young TL; Wiggs J; Olivier MMG; Quintanilla R; Arrieta E; Savatovsky EJ; Vanner EA; Parrish RKJournal of Glaucoma 2022; 31: 584-589
PRCIS: Glaucoma cascade screening in first degree relatives of young Haitian glaucoma patients had high yield for diagnosing manifest and suspected glaucoma in 30.8% of those screened despite modest participation. PURPOSE: To evaluate the outcomes of glaucoma cascade screening in first-degree relatives (FDRs; parents, siblings and offspring) of Haitian juvenile open angle glaucoma (JOAG) patients. PATIENTS AND METHODS: Consecutive index patients (Haitians with JOAG) were identified, and the number/type of FDRs residing in South Florida were recorded. These FDRs were invited for free glaucoma screening, which included a comprehensive ophthalmic exam, gonioscopy, automated visual field testing and optical coherence tomographic analysis of the retinal nerve fiber layers. FDR characteristics and clinical findings from screening are reported. RESULTS: A total of 77 FDRs were invited, 26 (33.8%) agreed to undergo screening (18 females, 9 males), which revealed 2 (7.7%) with manifest glaucoma (mean age 77.5▒y; one of whom was previously unaware of his glaucoma diagnosis), 6 (23.1%) with suspected glaucoma (mean age 29.8±18.3▒y), and 18 (69.2%) without manifest or suspected glaucoma (mean age 37.2±21.8▒y). Siblings of index patients were least likely to participate in cascade glaucoma screening when compared to index patients' parents or offspring. FDR eyes with manifest glaucoma had significantly worse best-corrected visual acuities, higher intraocular pressures, thinner central corneal thicknesses, and thinner circumferential papillary retinal nerve fiber layer thicknesses than those without glaucoma. CONCLUSION: Glaucoma cascade screening of Haitian JOAG patients' FDRs revealed that 30.8% had suspected or manifest glaucoma. Future efforts centered on provider-initiated recruitment and improving public glaucoma awareness and education may increase screening participation.
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Ocular Genomics Institute, Harvard Medical School, Boston, Massachusetts Rosalind Franklin University of Medicine and Science/The Chicago Medical School, North Chicago, Illinois.
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