advertisement
Abstract #98778 Published in IGR 22-4
Polymorphisms in gene and the risk of suffering Primary Open-Angle Glaucoma: Systematic review and meta-analysis
Calero-Dueñas N; Mateos-Olivares M; Ussa F; Juberías JR; Marcos M; Pastor-Idoate S; Usategui-Martín REuropean Journal of Ophthalmology 2022; 0: 11206721221077621
PURPOSE: It had been reported that mutations in gene probably play an important role in the pathogenesis of primary open angle glaucoma (POAG) but the existing genetic association studies show contradictory results. Thus, the objective of our study was to perform a systematic review and meta-analysis to characterize more precisely the potential association between given polymorphisms in gene and the risk of suffering POAG. METHODS: A systematic review of studies that related the risk of carrying gene polymorphisms with POAG development was conducted. We selected 19 case-control studies including 3855 POAG patients and 4125 control subjects in our meta-analyses. A random effects model was used. Sensitivity analysis and assessment of bias were also included. RESULTS: The prevalence of gene polymorphisms were significantly more frequent among POAG patients compared to all controls (OR = 2.91, 95% CI = 1.37 - 6.21; P = 0.006). Moreover, their prevalence was significantly higher in juvenile-onset patients than in adult-onset ones (OR = 2.27, 95% CI = 1.20-4.28; P = 0.001). CONCLUSION: The results of this meta-analysis uphold that being a carrier of polymorphic genetic variants in gene would increase the risk of POAG, especially the juvenile onset.
16383Bellvitge University Hospital, Hospitalet de Llobregat, Spain.
Full article