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Abstract #99040 Published in IGR 22-4
Progression of Visual Field Damage within Clusters Depends on Preexisting Damage
Burkart L; Freiberg F; Orguel S; Orgül SKlinische Monatsblätter für Augenheilkunde 2022; 239: 443-448
PURPOSE: To investigate, in a routine clinical setting, how global progression or progression within visual field clusters depends on preexisting damage. METHODS: Glaucoma patients with a visual field damage of at least 3 dB at baseline and a series of at least 5 good quality examinations were scrutinized retrospectively. The change in visual field damage within 10 visual field clusters was assessed in a mixed linear effects model with age, baseline global mean deviation (MD), baseline cluster MD, and observation time as covariates. In addition, progression was tested for a global MD rate with age, baseline global MD, and observation time as covariates. RESULTS: A total of 50 patients with a mean (± SD) age of 78 (± 13) years and a baseline global mean defect (MD) of 7.6 dB (± 4.4) fulfilling the selection criteria were identified between 2001 and 2019 out of 5019 patients in a visual field database of a tertiary ophthalmology center. Baseline visual field damage (global MD) correlated positively (p < 0.001) with the progression rate within clusters, but not with the global MD rate (p = 0.075). Higher age was a significant predictor for more rapid progression in both models (p < 0.001). CONCLUSION: In this retrospective study of patients in a routine clinical setting, who were not enrolled in studies, and simply receiving routine clinical care, analyzing progression within visual field clusters was more sensitive than assessing the global MD rate.
Augenklinik, Stadtspital Triemli, Zurich, Switzerland.
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