advertisement
Abstract #9905 Published in IGR 5-3
Ocular hypotensive effect of nipradilol ophthalmic solution for normal-tension glaucoma
Yukawa E; Taketani F; Matsuura T; Nitta N; Ishibashi H; Morishita K; Hara YJapanese Journal of Clinical Ophthalmology 2003; 57: 1471-1475
The authors evaluated the ocular hypotensive effect of nipradilol ophthalmic solution in 41 eyes of 41 patients of normal-tension glaucoma. In these cases, intraocular pressure (IOP) had never exceeded 21 mmHg. All the eyes had glaucomatous disc excavation corresponding to the visual field defects. Ages ranged from 32-83 years, average 63 years. IOP was 15 mmHg or over in 21 eyes and averaged 17.9± 1.8 mmHg. It was less than 15 mmHg in 20 eyes and averaged 12.6±1.1 mmHg. IOP decreased significantly during six months after start of nipradilol (p < 0.05). Outflow pressure decreased moderately or more in 14 of 21 eyes (67%) and in 15 of 20 eyes (75%). Instillation of nipradilol promises to be beneficial for normal-tension glaucoma because of its hypotensive effect through α1 - and β-blockage, increase of intraocular circulation, and neuroprotective actions. LA: Japanese
Dr. E. Yukawa, Department of Ophthalmology, Nara Medical University, 840 Shijyo-cho, Kashihara-shi, 634-8522, Japan
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
