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Abstract #99076 Published in IGR 22-4
Structure-function analysis of MP3 microperimetry versus Octopus perimetry in central glaucomatous visual field defects
Georgiev S; Palkovits S; Hirnschall N; Schlatter A; Leisser C; Findl OOphthalmic Research 2022; 0:
INTRODUCTION: To compare the structure-function relationship with microperimetry and Octopus perimetry in primary open angle glaucoma (POAG) patients with central visual field (VF) defects. METHODS: 40 eyes of 24 patients with POAG were enrolled. Circumpapillary retinal nerve fiber layer (cpRNFL) analysis measured by spectral-domain optical coherence tomography (SD-OCT) of the superotemporal, temporal, and inferotemporal optic nerve head (ONH) sectors were related to corresponding microperimetric and Octopus VF clusters using the G2 grid-pattern with dynamic strategy, respectively. The structure-function relationships of both devices were assessed via a segmented regression, as well as linear regression across overall SD-OCT cpRNFL values and outside normative (<1%) SD-OCT cpRNFL values. RESULTS: Linear and segmented regression fits were similar with both devices. Across overall cpRNFL sectorial values, structure-function relations for the superotemporal, temporal and inferotemporal sectors were R2=0.176 (p=<0.001), R2=0.008 (p=0.069), and R2=0.294 (p=<0.001) for microperimetry, and R2= 0.189 (p=<0.001), R2= 0.020 (p=0.002), and R2= 0.326 (p=<0.001) for Octopus perimetry. For corresponding values outside normative limits (<1%), the relationships were R2=0.113 (p=<0.001), R2=0.001 (p=0.836), and R2=0.420 (p=<0.001) for microperimetry, and R2= 0.192 (p=<0.001), R2= 0.002, (p=0.336), and R2= 0.366 (p=<0.001) for Octopus perimetry. DISCUSSION/CONCLUSION: Structure-function analysis was similar for both devices. Fundus-tracking should be further evaluated in a longitudinal setting in patients affected by glaucoma.
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