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Abstract #9924 Published in IGR 5-3
Effect of latanoprost on diurnal variations of intraocular pressure in normal-tension glaucoma
Nakamoto K; Yasuda N; Nanno M; Kinohira Y; Murai K; Fukuda TNippon Ganka Gakkai Zasshi 2003; 107: 530-534
OBJECTIVES: To study the effect of instillation of latanoprost on the diurnal variation in the intraocular pressure (IOP), blood pressure, and pulse rate in patients with normal-tension glaucoma (NTG). SUBJECTS AND METHODS: Diurnal variation in IOP was determined in 23 eyes in 23 NTG patients after a washout period of four weeks or longer. Diurnal variation in IOP was then remeasured after latanoprost monotherapy of eight weeks or longer. IOP was measured by Goldmann applanation tonometry at 10.00, 13.00, 16.00, 19.00, 22.00, 01.00, 03.00, 07.00, and 10.00 hours before and after treatment, and IOP at each time point, mean diurnal IOP, maximum and minimum IOP, and range of variation in IOP were compared before and after treatment. Blood pressure and pulse rate before and after treatment were also measured and compared. RESULTS: IOP decreased significantly at all time points. The treatment caused significant decreases in mean diurnal IOP, maximum and minimum IOP, and range of variation in IOP. There were no differences in blood pressure or pulse rate before and after treatment. CONCLUSIONS: Latanoprost significantly decreases IOP throughout the day in NTG patients, and has no effects on blood pressure or pulse rate. Therefore, it is useful in the treatment of NTG. LA: Japanese
Dr. K. Nakamoto, Department of Ophthalmology, Tokyo Metropolitan Police Hospital, 2-10-41 Fujimi, Chiyoda-ku, Tokyo 102-0071, Japan
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
