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Abstract #99251 Published in IGR 22-4
Development and Validation of the Iris Glare, Appearance and Photophobia (Iris GAP) Questionnaire for Patients with Iris Defects
Kryshtalskyj MT; Rai AS; Durr GM; Ahmed IIKJournal of Cataract and Refractive Surgery 2022; 48: 1141-1147
PURPOSE: To validate the Iris Glare, Appearance and Photophobia (Iris GAP) Questionnaire, a novel symptom- and appearance-based quality-of-life measure for patients with iris defects.t. SETTING: Single tertiary glaucoma clinic in Toronto, Ontario, Canada. DESIGN: Prospective cohort study. METHODS: Participants included 73 patients with iris defects, 68 controls with no iris defects, 77 patients with peripheral iridotomies or transillumination defects, and 22 patients with surgically repaired irises (n=22). Patients completed the Iris GAP questionnaire and the glare and driving subscales of the Refractive Status and Vision Profile (RSVP) questionnaire. Test-retest reliability, defined by Cronbach α and intraclass correlation coefficients (ICC), was evaluated with repeat testing two weeks later. RESULTS: Iris GAP scores ranged from 0-32 with a 97% completion rate. Iris GAP had high test-retest reliability (Cronbach α=0.866, ICC=0.953, p<0.0005). Iris GAP scores were reliably distinguishable between patients with iris defects, repaired iris defects, peripheral iridotomies (PIs) and transillumination defects (TIDs), and controls (one-way ANOVA p<0.0005). In pairwise comparisons, the major defect group had statistically significantly higher scores than any of the other groups (p<0.005 for each). The control and repaired groups had the lowest scores, while the PI/TID group had intermediate scores. Nine patients underwent iris repair between tests and had a mean difference of 8.2 ± 6.2 points between their pre-operative and post-operative scores (p=0.004). Iris GAP scores positively correlated with RSVP scores (R2 =0.73). CONCLUSIONS: Iris GAP can reliably evaluate symptomatology and patient-reported appearance in patients with iris defects.
Department of Surgery (Section of Ophthalmology), University of Calgary. Eye Clinic, Rockyview General Hospital. Main (4th) Floor, 7007 14 Street SW, Calgary, AB, Canada. T2V1P9.
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