advertisement
Abstract #9989 Published in IGR 5-3
Ciliary body toxicity of cyclosporin A and octreotide acetate in rabbit eyes: a comparison with mitomycin C and 5-fluorouracil
Akyol N; Demir T; Çobanoglu B; Ula FGraefe's Archive for Clinical and Experimental Ophthalmology 2003; 241: 816-822
PURPOSE: To compare the toxicities of cyclosporin A, octreotide acetate, mitomycin C and 5-fluorouracil to the ciliary body. METHODS: The authors applied sponges soaked in these compounds to the open scleras of rabbit eyes. Histopathological specimens were obtained from the operation site and at 180° from it on the 14th day after surgery. RESULTS: Mean ciliary epithelial thickness in the study groups was as follows: 12.29 ± 2.69 m in group 1 (mitomycin C), 13.85 ± 4.56 m in group 2 (5-fluorouracil), 17.71 ± 3.09 m in group 3 (cyclosporin A), 11.64 ± 2.92 m in group 4 (octreotide acetate), 11.92 ± 2.89 m in group 5 (topically applied octreotide acetate) and 21.85 ± 4.29 m in group 6 (control). The ciliary epithelial thickness in groups 1, 2, 4 and 5 was statistically different from that in the control group. Intracellular vacuolization and degenerative changes of the non-pigmented epithelium, and pigment loss of the pigmented epithelium, were found mostly in group 1 and moderately in group 2 and 3. CONCLUSION: Octreotide acetate and cyclosporin A are less toxic alternatives to mitomycin C and 5-fluorouracil in glaucoma filtration surgery.
Dr. N. Akyol, Department of Ophthalmology, Frat University Medical School, Göz Hastalklar AD, 23200 Elazg, Turkey. nakyol@firat.edu.tr
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)