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Abstract #9997 Published in IGR 5-3
The distribution of 5-fluorouracil in eye after subconjunctival injection
Xiong X; Li J; Qi SChinese Ophthalmic Research 2003; 21: 377-378
OBJECTIVE: To investigate the distribution of 5-fluorouracil (5-Fu) after the subconjunctival injection in normal eyes and eyes followed trabeculectomy. METHODS: Nine rabbits (18 eyes) underwent trabeculectomy while a further nine served as normal controls. 5 mg of 5-Fu was injected into all eyes at 3 o'clock once daily five times. The animals were sacrificed on one, three, and ten days after the last injection. The conjunctival tissue at the operative site, cornea, lens, retina near the papilla, and 0.2 ml aqueous humor were taken in order to detect fluorine using ion-selective electrodes. RESULTS: As time went on, the concentration of 5-Fu declined in the cornea but increased in the retina. The amount of 5-Fu in the aqueous humor and lens was low and remained constant, but first rose and then dropped in the conjunctiva. CONCLUSIONS: Distribution of 5-Fu in the eye is not associated with the injection site but with the amount and activity of the cells in those tissues. The highest concentration of 5-Fu in the retina after subconjunctival injection may have potential toxicity to visual function. LA: Chinese
Dr. X. Xiong, Department of Ophthalmology, Union Hospital, Huazhong University of Science/Technology, Wuhan 430022, China
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
