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Abstract #10022 Published in IGR 5-3
A light-activated surgical adhesive technique for sutureless ophthalmic surgery
Bloom JN; Duffy MT; Davis JB; McNally-Heintzelman KMArchives of Ophthalmology 2003; 121: 1591-1595
OBJECTIVE: To investigate a scaffold-enhanced, light-activated bioadhesive technique as a substitute for sutures in ophthalmic surgery. CLINICAL RELEVANCE: Suture use in ophthalmic surgery is technically demanding and time consuming and may be associated with serious complications such as inadvertent ocular penetration, which can result in retinal detachment and endophthalmitis. Bioadhesive surgery could eliminate many complications and limitations associated with the use of sutures. METHODS: The bioadhesive was composed of a poly(L-lactic-co-glycolic acid) (PLGA) porous scaffold doped with a protein solder mix composed of serum albumin and indocyanine green, which was activated with a diode laser. Extraocular rectus muscle-to-extraocular rectus muscle, sclera-to-sclera, and extraocular rectus muscle-to-sclera adhesions were created in freshly harvested tissue followed by tensile-strength testing of these surgical adhesions. RESULTS: Optimum tensile strength for muscle-to-muscle repair was achieved with 50% wt/vol bovine serum albumin and 0.5 mg/ml of indocyanine green saturated into a PLGA porous scaffold and activated with an 808-nm diode laser. The tensile strength was 81% of the native muscle's tensile strength (mean ± SD, 433 ± 70 g versus 494 ± 73 g). Sclera-to-sclera adhesions achieved a mean ± SD tensile strength of 295 ± 38 g, whereas that for extraocular rectus muscle-to-sclera adhesions was 309 ± 37 g. CONCLUSION: Sutureless surgery using this bioadhesive technique for various ophthalmic procedures appears feasible and may result in reduced surgical complications and cost.
Dr. J.N. Bloom, Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA. jbloom@uic.edu
Classification:
12.20 Other (Part of: 12 Surgical treatment)
